[ad_1] Abstract Background: Mucopolysaccharidosis type III (MPS III or Sanfilippo syndrome) is a lysosomal storage disease resulting in progressive neurocognitive decline during childhood and early demise. Its diagnosis may have a great impact on parents,…
Read More[ad_1] Abstract The differential impact of distinct antiestrogens (AEs) is the result of varying structural perturbations they confer to estrogen receptors (ERs) when these small-molecule synthetic compounds compete with endogenous hormones, such as 17β-estradiol. These…
Read More[ad_1] Abstract Background: There is minimal information available about acute hepatic porphyrias (AHPs) in developing countries. The aim of this study was to describe the demographics, clinical features, and mortality of AHPs in Colombia. Patients…
Read More[ad_1] Abstract Currently, neuroprotective strategies mainly aim to decrease bleeding from cerebral arteries and protect the insulted neurons in the hemorrhagic stroke. However, the role of cerebral venous system in the pathophysiology of hemorrhagic stroke…
Read More[ad_1] Abstract Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of…
Read More[ad_1] Abstract Lathosterolosis is a rare defect of cholesterol synthesis. Only four previous cases have been reported, two of whom were siblings. We report a fifth patient, with a relatively mild phenotype. He presented at…
Read More[ad_1] Abstract Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism whose dietary treatment involves uncooked cornstarch administration and restriction of simple carbohydrate intake. The prevalence of feeding difficulties (FDs) and orofacial myofunctional disorders…
Read More[ad_1] Abstract Dietary phenylalanine restriction in phenylketonuria (PKU) patients is usually mandatory in order to prevent cognitive impairment. The influence of a low-protein diet on growth has raised concerns in families and caregivers. This paper…
Read More[ad_1] Abstract In the field of toxicology or environmental science, some researchers are wondering a question. That is, whether specific molecular signaling pathways in response to certain environmental toxicants or stresses exist in organisms. We…
Read More[ad_1] ABSTRACT The antiviral activities of plant leaves extract of four species, were investigated. The extract were tested for antiviral activities on the host plant (Cocumba) against Moroccan watermelon mosaic virus. Results showed that two…
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